After researching the long-term effects of Letrozole, I've discovered that this medication is primarily used to treat hormone receptor-positive breast cancer in postmenopausal women. While it's been proven to be effective, patients may experience side effects such as hot flashes, joint pain, and fatigue. Moreover, some studies suggest that long-term use of Letrozole could lead to bone density loss, raising concerns about osteoporosis. However, the overall benefits of this drug tend to outweigh the risks for most patients. It's essential to consult with your healthcare provider to determine if Letrozole is right for you and to monitor any potential side effects.