Nasonex vs Flonase: Which Nasal Spray Works Better for Allergies?

When it comes to managing seasonal allergies, Nasonex, a prescription steroid nasal spray containing mometasone furoate and Flonase, an over-the-counter option with fluticasone propionate are two of the most talked-about choices. Both are steroid nasal sprays, anti-inflammatory medications designed to reduce swelling and mucus in the nasal passages, but they’re not the same. One requires a prescription. The other doesn’t. One is FDA-approved for kids as young as two. The other starts at age four. And while they both target the same problem—runny nose, sneezing, congestion—they do it with different strengths, side effects, and costs.

So why does this matter? Because picking the wrong one can mean wasted money, unnecessary side effects, or worse—no relief at all. Nasonex is often prescribed for people with more persistent or severe symptoms, especially those who also have nasal polyps. Flonase, on the other hand, is a go-to for everyday allergy sufferers who want quick, affordable access without a doctor’s visit. Both work over time, not instantly, and both need daily use for full effect. But here’s the thing: some people respond better to one than the other. It’s not just about the active ingredient—it’s about how your body reacts to the formulation, the delivery system, and even the scent. A study in the Journal of Allergy and Clinical Immunology found that while both drugs reduced nasal symptoms by about 60% on average, individual results varied widely. One person might swear by Flonase. Another might find Nasonex clears their sinuses without the bitter aftertaste.

Cost is another big factor. Flonase is cheaper because it’s available as a generic and sold over the counter. Nasonex, even with insurance, often costs more. But if your symptoms are tied to chronic sinus issues or polyps, Nasonex might be your only effective option. And if you’re treating a child, age restrictions matter. Nasonex can be used in kids as young as two, while Flonase is approved for kids four and up. Neither is meant for short-term relief like decongestant sprays. They’re long-term tools. You need to use them every day, even when you feel fine.

Below, you’ll find real comparisons from people who’ve tried both. Some switched after one didn’t work. Others stuck with one because it was easier to get. We’ve pulled together guides on how these sprays stack up against other treatments, what side effects to watch for, and how to know if you’re getting the most out of your medication. Whether you’re dealing with spring pollen, dust mites, or year-round congestion, the right spray can change your life. Let’s see what works—and what doesn’t—for real users.