Clindamycin: What it treats and how to use it safely

Clindamycin is an antibiotic many doctors prescribe for skin infections, dental abscesses, some lung infections, and bacterial vaginosis. You’ll find it as oral capsules, liquid, topical gels, and a vaginal cream. Each form targets different problems, so the way you use it matters.

Why would a doctor pick clindamycin over other antibiotics? It works well against certain bacteria that resist other drugs. That makes it handy when penicillin isn’t an option or when a specific bug is known to respond to clindamycin.

When is clindamycin used?

For skin issues like infected acne or cellulitis, topical clindamycin (usually 1% gel or lotion) is common. For dental infections, skin abscesses, and some respiratory infections, oral clindamycin is used. Vaginal clindamycin cream treats bacterial vaginosis. Your prescription will say which form and how long to use it—follow that.

Typical oral doses vary by infection: low to moderate infections might use 150–300 mg every 6–8 hours; more serious cases use higher doses. Topical products are usually applied twice a day. Don’t change the dose on your own—ask your prescriber if you think it’s not working.

Side effects and what to watch for

The most common side effects are stomach upset, diarrhea, nausea, and sometimes a skin rash. One serious risk with clindamycin is Clostridioides difficile (C. difficile) infection, which causes severe, persistent diarrhea. If you have watery diarrhea more than a few times a day, or fever and belly pain, contact your doctor right away.

Other warnings: clindamycin can interact with neuromuscular-blocking drugs used during surgery and may cause more weakness. People with liver problems should use it carefully—tell your doctor about any liver disease. If you’re pregnant or breastfeeding, talk to your healthcare provider about risks and benefits.

How to take it wisely: take oral clindamycin with a full glass of water to avoid throat irritation. Finish the full course even if you feel better; stopping early can let the infection return or lead to resistance. Don’t share antibiotics or use leftover medicine for a new illness.

Topical clindamycin can make skin drier or cause irritation—try it on a small area first if you’ve sensitive skin. For vaginal cream, follow instructions about timing and avoid sex until treatment is done unless your doctor says otherwise.

Final practical tips: keep a list of all medicines and supplements you take and show it to your provider. If you’ve had bad reactions to antibiotics before, mention that too. When in doubt, call your pharmacist or doctor—asking questions now can prevent bigger problems later.