When you pick up a generic pill, you want to know it’ll do the same job as the brand-name version. That’s where the AB rating, a classification used by the FDA to show that a generic drug is therapeutically equivalent to its brand-name counterpart. Also known as therapeutic equivalence code, it’s the quiet guarantee behind your prescription savings. If a drug has an AB rating, it means the FDA has tested it and confirmed it delivers the same amount of active ingredient at the same speed and in the same way as the original. No guesswork. No hidden differences. Just the same effect, at a lower price.
This isn’t just paperwork—it’s personal. If you’re switching from Lipitor to generic atorvastatin, or from Nexium to esomeprazole, the AB rating is what keeps your blood pressure, cholesterol, or acid reflux under control. Without it, you’d be taking a risk with your health just to save money. But with an AB rating, you can trust that the generic won’t cause unexpected side effects, drop your treatment effectiveness, or mess with how your body absorbs the drug. The FDA doesn’t give out AB ratings lightly. They check bioavailability, dissolution rates, and even how the pill breaks down in your gut. And they do it for every single generic that wants to carry that label.
Not all generics get an AB rating. Some are rated AB only for certain strengths or formulations. Others might be rated BX, meaning they’re not considered equivalent. That’s why you should always check the label or ask your pharmacist. You might see AB ratings listed on your prescription receipt or pharmacy app—look for those two letters. They’re your signal that the switch is safe. And if you’re comparing medications like Penegra and Viagra, or Nasonex and Flonase, the AB rating tells you whether one can truly replace the other without a doctor’s note.
Behind every AB-rated drug is a system built to protect you. It’s not about big pharma or cheap shortcuts. It’s about making sure that when you fill a prescription, you get what you’re promised. The posts below dive into real examples—how AB ratings affect your out-of-pocket costs, why some generics fail equivalence tests, and how to spot the difference between a safe swap and a risky one. You’ll also find guides on comparing medications like Azee DT and other antibiotics, or Dilantin and its alternatives, where AB ratings play a silent but critical role. Whether you’re managing statin side effects, switching antifungals, or trying to cut costs on ED meds, knowing what AB means can save you money, time, and stress.
Learn how to use the FDA Orange Book to verify if a generic drug is therapeutically equivalent to its brand-name counterpart. Understand TE codes, AB ratings, and common pitfalls in generic substitution.