Imagine your kidneys as a network of microscopic sieves, filtering waste from your blood every minute. Now imagine your own immune system, designed to protect you, turning against those sieves and smashing them apart. That’s what happens in glomerulonephritis - a condition where your body’s defense system mistakenly targets the glomeruli, the tiny filtering units inside your kidneys.

What Exactly Are the Glomeruli?

The glomeruli are not just simple filters. Each one is a complex structure made of three layers: the innermost endothelial cells lined with a sugar coating called the glycocalyx, the middle glomerular basement membrane (GBM), and the outer layer of specialized cells called podocytes. These podocytes have foot-like projections that wrap around capillaries, forming gaps so small only water and waste can pass through - proteins and blood cells should stay behind.

When glomerulonephritis strikes, immune cells and proteins invade this delicate system. Antibodies, complement proteins, or immune complexes pile up where they shouldn’t. This triggers inflammation, swelling, and scarring. As the filters break down, protein leaks into your urine (proteinuria), red blood cells escape (hematuria), and fluid builds up in your body, causing swelling in your ankles, face, or belly.

Two Main Faces of Glomerulonephritis

Not all cases look the same. Glomerulonephritis typically shows up in two major forms: nephritic syndrome and nephrotic syndrome.

Nephritic syndrome means your kidneys are inflamed and damaged from within. You’ll see blood in your urine, high blood pressure, reduced urine output, and rising creatinine levels - usually between 1.5 and 3.0 mg/dL. This form often follows infections like strep throat, especially in children. Post-streptococcal GN, for example, hits about 15% of kids with recent strep infections, but 95% recover fully within two months.

Nephrotic syndrome is different. Here, the filters are so damaged that massive amounts of protein - more than 3.5 grams a day - slip into the urine. Your blood loses protein, so fluid leaks out into tissues, causing severe swelling. Cholesterol and triglycerides spike, often above 160 mg/dL. This form is more common in adults and can be caused by conditions like lupus or IgA nephropathy.

The Most Common Types You Need to Know

There are several specific types of glomerulonephritis, each with its own trigger and pattern.

IgA nephropathy is the most common form worldwide. It happens when IgA antibodies - normally fighting infections - clump together in the glomeruli. In North America, it affects about 2.5 people per 100,000 each year. Over 20 years, 20 to 40% of those with IgA nephropathy will develop kidney failure.

C3 glomerulonephritis (C3G) is rarer but more aggressive. It’s not caused by antibodies, but by a runaway complement system - your body’s ancient immune alarm system. In C3G, the C3 protein builds up in the kidneys at levels 3 to 5 times higher than normal. About 60 to 70% of cases involve an autoantibody called C3 nephritic factor (C3NeF), which keeps the complement system stuck in “on” mode.

Immune complex-mediated membranoproliferative GN (IC-MPGN) is caused by immune complexes - clumps of antibodies and antigens - lodging in the glomeruli. Biopsies show dense deposits in 95% of cases. Unlike C3G, IC-MPGN is often linked to chronic infections like hepatitis or autoimmune diseases like lupus.

Lupus nephritis, which affects half to two-thirds of people with systemic lupus erythematosus (SLE), is another major type. With modern treatment, 70 to 80% of patients avoid kidney failure within 10 years - but without treatment, the outcome is far worse.

Why Do Podocytes Matter So Much?

Podocytes are the unsung heroes of the glomerulus. They don’t regenerate easily. Once they’re damaged, they can’t be replaced. That’s why immune attacks on podocytes are so dangerous.

As Dr. Richard Johnson from the University of Colorado explained, podocytes have receptors that make them targets for inflammatory signals. They also produce their own inflammatory chemicals, creating a feedback loop of damage. When these cells die or pull away from the filter, protein leaks out - and the damage becomes permanent.

This is why treatments that just suppress the whole immune system - like high-dose steroids - often fail. They don’t fix the root problem. They just slow the attack, often at the cost of serious side effects.

How Is It Diagnosed?

There’s no blood test that confirms glomerulonephritis. The only way to know for sure is a kidney biopsy.

A biopsy involves inserting a thin needle through the back to collect a tiny sample of kidney tissue. It’s safe for most people, but carries a 3 to 5% risk of bleeding or pain. The real challenge? Interpreting the sample. Nephropathologists - kidney pathologists - need 5 to 7 years of training to tell the difference between C3G, IC-MPGN, IgA nephropathy, and other variants under the microscope.

New tools are helping. In 2023, the European Renal Association introduced a classification system that combines traditional biopsy findings with molecular biomarkers. This new method predicts treatment response with 85% accuracy - compared to just 65% using biopsy alone.

Treatment: Steroids, Side Effects, and New Hope

For decades, the go-to treatment has been corticosteroids like prednisone. About 60 to 80% of patients respond at first. But here’s the catch: 30 to 50% of them experience treatment failure over time, and nearly 70% report major side effects.

Weight gain? Common. Infections? 35% higher risk. Bone fractures? 28% of patients lose bone density within a year. One patient on a support forum described two vertebral fractures from prednisone in just 18 months.

That’s why new drugs are changing the game.

In 2023, the FDA gave breakthrough status to iptacopan, a drug from Novartis that blocks a key part of the complement system. In trials, it cut proteinuria by 52% in C3G patients - without the broad immune suppression of steroids. But there’s a catch: it costs about $500,000 a year.

Other targeted therapies, like eculizumab, also show promise but are similarly expensive. The good news? More drugs are in development. The bad news? Access is wildly unequal. In low-income countries, patients have 90% less access to these new treatments than those in the U.S. or Europe.

What Do Patients Really Experience?

Behind the numbers are real people.

A 2022 survey by the American Kidney Fund found that 65% of GN patients struggle with constant fatigue - more than swelling or pain. On online forums, 78% of posts mention trouble managing swelling. 63% worry about steroid side effects. Half fear their kidneys will fail.

One Reddit user shared that starting rituximab within two months of diagnosis kept them off dialysis. Another said it took 4.2 months and three specialists to get a diagnosis. Many feel lost in a system that treats them like a case number, not a person.

What’s Next for Glomerulonephritis?

The future of GN treatment is personalization. Researchers are now mapping genetic profiles and protein patterns to predict who will respond to which drug. Dr. Richard Lafayette from Stanford predicts that within five years, we’ll choose treatments based on a patient’s unique biology - not guesswork.

That could raise success rates from 60-70% to over 85%.

But progress won’t mean much if it’s only available to the wealthy. The global GN treatment market is projected to hit $4.7 billion by 2028. That growth is real - but so is the inequality.

For now, early diagnosis and careful monitoring remain the best tools. Regular blood tests for creatinine, monthly urine checks for protein, and blood pressure control can slow damage - even before new drugs become accessible.

Bottom Line

Glomerulonephritis isn’t one disease. It’s a family of immune attacks on the kidney’s most delicate structures. Some forms heal on their own. Others demand aggressive, targeted treatment. The old approach - blanket immunosuppression - is fading. The new era is about precision: stopping the right part of the immune system, at the right time, with fewer side effects.

If you’ve been told you have protein in your urine or blood in your urine, don’t ignore it. See a nephrologist. Push for a biopsy if needed. And know this: you’re not alone. Thousands are walking the same path - and science is finally catching up to them.