Mixing imipramine with over-the-counter drugs like antihistamines, decongestants, and pain relievers can cause serious side effects. This guide breaks down the most risky combinations, common symptoms to watch out for, and offers practical advice for staying safe. Learn the actual reasons behind these interactions – and what your pharmacist wishes you’d ask. From drowsiness risks to blood pressure problems, we cover the real-world impact, so you don’t get blindsided. Don’t let a careless cold or headache remedy undo your mental health progress.